Evaluation of Antiangiogenesis Activity of Myristica Malabarica Leaves

AIM AND OBJECTIVE: Cancer is a one of the life threatened disease in this world and now a days which may appeared worldwide problem. As per the literature survey, globally one in five men and one in six women will develop cancer before the age of 75 and one in eight men, and one in twelve women, will die from the disease. Nearly seven lakh Indians die of cancer every year, while over 10 lakh are newly diagnosed with some form of the disease. Several modern day synthetic drugs are available in market do not full fill the requirements with side effects like allopecia, cytotoxicity, bone marrow depression etc. So the priority is drugs which minimize the side effects and also require a chemical entity for the treatment of cancer. Several literatures indicated traditional herbs possessing lesser side effects compared to synthetic drugs. The herbal formulations were developed from Ayurveda, traditional system of Indian medicine and its additional systems of medicine, has been found to have anticancer activity. Some of the research workers published has been published my study related species like Myristica Fragrance possess anti-cancer activity. Myristica Malabarica is a traditionally used herb but there is no scientific validation which old version of books and oliaichuvadi (Palmleaf petal writings) anti angiogenesis activity. Based on the above information’s I was selected the plant, perform the extraction and current work aims for identification of anticancer constituents from the fruits of Myristica Malabarica and evaluated by using some in vitro technique. DISCUSSION AND CONCLUSSION: Angiogenesis is a hallmark of tumor development and metastasis and is now a validated target for cancer treatment. However, the survival benefits of antiangiogenic drugs have, thus far, been rather modest, stimulating interest in developing more effective ways to combine anti-angiogenic drugs with established chemotherapies. New targets for anti-angiogenesis continue to be discovered, increasing the opportunities to interdict tumor angiogenesis and circumvent resistance mechanisms that may emerge with chronic use of these drugs. The control of tumor angiogenesis is an integral part of the host defense response to tumor growth. Loss of endogenous angiogenesis inhibitors, such as endostatin and thromobospondin-1, leads to increased tumor angiogenesis and accelerates tumor growth. The inhibition of tumor growth by anti-angiogenic drugs has been achieved both in preclinical studies and in clinical trials, where promising anti-tumor responses have been reported for a variety of anti-angiogenic agents The survival benefits of anti-angiogenic drugs have, thus far, been rather modest, leading to increased interest in developing more effective ways to combine anti-angiogenic drugs with traditional, cytotoxic chemotherapies. In this review, we discuss recent progress and some emerging challenges in the development of antiangiogenic drugs for cancer treatment. Tumors need to develop their own blood vessels in order to survive, proliferate and invade other tissues, making antiangiogenesis an interesting target for antitumor therapy. Treatments can be direct, targeting membrane receptors, indirect, targeting angiogenic factors or both. Using chick CAM model ,the new pharmacological effect of Myristica malabarica extract have been confirmed by the proven inhibition of angiogenesis. It showed that significant antiangiogenic activity of all hours of treatment studied and extract studies. The antiangiogenic property of Myristica malabarica may be attributed to the phytochemical present in the plant .It could be function of either the individual or the additive effect of phytoconstituents may be phenol, terpinoids, and flavanoids have shown to inhibit carcinogenisis and tumerogenisis. From qualitative phytochemical analysis the presence of alkaloids ,flavanoids and terpinoids may be atributed to the potential antiangiogenic property . The strong antiangiogenic properties of this plant support the ethnomedical claim of the Myristica malabarica