Design and Development of Gliclazide Matrix Tablets Using HPC, HPMC and their Combination as a Release Retarding Polymers

In present investigation an attempt has been made to design and develop some Gliclazide matrix tablets using Hydroxy propyl cellulose, Hydroxy propyl methyl cellulose and their combination as release retarding polymers. Gliclazide is oral hypoglycaemic drug which lowers blood glucose level and has been selected to prepare sustained release dosage forms. Gliclazide sustained release matrix tablets were prepared using Hydorxy Propyl Cellulose, Hydroxy Propyl Methyl Cellulose and their combination as base polymer by wet granulation method. FT-IR spectral analysis showed that characteristic peak of Gliclazide pure drug was retained in the spectra of all the formulations indicating the inactness of the drug in all the formulations. The prepared tablets were evaluated for number of parameters like thickness, diameter, weight variation, swelling index and in vitro release studies. All the prepared tablets were of smooth surface and elegant texture. The tablets prepared were checked visually for its appearance & surface texture. The weights of the tablets were in the range of 250 ± 5 mg. The thickness of the tablet was in the range of 4.45 ± 0.11 mm to 4.51 ± 0.12 mm Gliclazide matrix tablets formulated employing HPMC K-4M and combination of HPMC K-4M and HPC 75-100 provided slow and controlled release of Gliclazide up to 12 hr. Drug release from the matrix tablets formulation containing HPMC K-4M and HPC 75-100 follows first order drug release with non-fickian diffusion. All the tablet formulation showed compliance with pharmacopoeial standard. As the time increases, the swelling index was increased; later on it decreases Gradually due to dissolution of outermost –gelled layer of tablet into dissolution medium. Comparison between HPMC K-4M, HPC 75-100 and their combination it has been observed that swelling index of HPMC K-4M was significantly more compared to HPC 75-100. Whereas swelling index in case of HPC 75-100 is less as compare to HPMC K-4M and HPC 75-100 combination. The dissolution result shows that an increased amount of polymer resulted in reduced drug release. A concentration dependent drug release is evident in case of the polymer i.e., lower concentration of polymers, release is marginally retarded at higher concentration is considerable. Prepared matrix formulation containing HPMC K-4M (F6 ), HPMC K-4M and HPC 75-100 combination (F9 ) probably showing better release based up to 98 % to 99 % drug release within 12 hour