Formulation Development and Invitro Evaluation of Famotidine Gastroretentive Tablets by Melt Granulation Technique

The aim of present work is to prepare floating tablets of famiotidne Hydrochloride using HPMC K4M, HPMC K15M and HPMC K100M as polymer. Floating drug delivery system have a bulk density less than gastric fluids and so remains buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. Famotidine an a histamine H2 receptor antagonist and used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). The short half life of famotidine, shorter resident in stomach and multiple administration dose make famotidine a very good candidate for formulation of floating drug delivery system. Floating tablets of famotidine were prepared by melt granulation method using HPMC K4M, HPMC K15M and HPMC K100M. The floating tablets was evaluated such as weight variation, hardness, friability, thickness, drug content, , invitro buoyancy, drug polymer compatibility (IR study ), and invitro dissolution studies of tablets. The micromeritic properties was found to be good, invitro buoyancy and invitro dissolution studies confirmed their good release nature. Formulation F4 prepared with of HPMC K100M shows a good invitro buoyancy lag time & floating time and invitro dissolution studies shows a 96.78% release for a period of 12 hrs. The data obtained in this study thus suggest that a floating tablets of famotidine are promising for sustained drug delivery which can reduce dosing frequency