Development of Bioresponsive Chronopharmaceutical Drug Delivery System in Treatment of Asthma & Copd Using Colon Targeted Mucoadhesive Tablets in Capsule System

AIM & OBJECTIVES : The main aim of the project was to develop a delivery system that claims the futuristic approach in the field of pharmaceutical science based on bioresponsiveness and timed delivery of drugs into the body. The objective of the present study is to develop the delivery system and to evaluate its delivery profile based on triggered release, timed release and site targeting. Salbutamol sulphate was chosen as the model drug for the present study to designa dosage form for treatment of asthma. Carbopol 971 P and eudragit E was chosen as key ingredients in the formulation to attain goal in this study. The development of tablets-filled-capsule systems offer benefits for the production of sustained release multiple unit dosage form. This system has specific advantages over conventional single unit dosage forms. Advantages of multiple unit dosage forms such as Mini-tablet-in capsule systems include a lower risk of dose dumping, less inter and intra such variability and a high degree of dispersion in the digestive tract, thus minimizing the risks of high local drug concentrations. Oral drug delivery represents by far the most common & convenient way of drug delivery. The gastro-Intestinal tract is still the route of choice for drug administration & absorption. Chronopharmaceutics is a branch of pharmaceutics devoted to design and evaluation of drug delivery system that release a bioactive agent at a rhythm that ideally matches the biological requirement of a given disease therapy. Ideally chronopharmaceutical drug delivery system (ChrDDS) should embody time controlled and site specific drug delivery system. A Bioresponsive drug delivery system is necessary since it works on the mechanisms capable of responding to physiological variations in the body, in order to synchronize drug- release profiles with changing physiological conditions.CONCLUSION: Chronopharmaceutical drug delivery can be used in case of diseases which shows circadian rhythm in their patho physiology which can tackle the problems as it is modulated to release the drug according to the biological clock. Hence, a smarter drug delivery system is needed which alters drug release profile itself based on severity of asthma attacks and COPD. This benefits the maintenance of drugs in plasma and also releases more of the drug it holds when condition is severe based on the needs of the physiological system