Formulation And Evaluation of Famotidine Beads as Controlled Drug Delivery System

In the present study an attempt was made to formulate sustained release microbeads of Famotidinefrom sodium alginate with different release modifiers such as HPMC K4M, Carbopol 71G and Pectin so as to enhance bioavailability and to reduce dosing frequency of the selected drug. In conclusion, ionotropic gelation and cross linking technique can be used for preparations of Famotidinemicro beads from sodium alginate with other release modifiers like HPMC K4M, Carbopol 71G and Pectin. Prepared microbeads showed higher drug entrapment and prolonged release characteristics. Famotidine release from micro beads was influenced by the proportion of alginate and release modifiers.. The beads formed have a spherical shape with rough surface as evidenced by SEM. The result of in vitro release and release kinetic indicated sustained release and exhibited zero order kinetic followed by super caseII- transport. Therefore, one can assume that the Famotidine micro beads are promising pharmaceutical dosage forms by providing sustaining effect and thereby improving the bioavailability. Therefore this developed sodium alginate micro beads with release modifier could be used as a carrier for the sustained delivery of other categories of drugs. The entire process is feasible in an industrial scale and demands pilot study