Formulation and Evaluation of Sustained Release Mucoadhesive Ciprofloxacin HCL Microparticles.

This study is to develop, characterize, and evaluate mucoadhesive microspheres of Ciprofloxacin employing various mucoadhesive polymers for prolonged gastrointestinal absorption. Mucoadhesive are preferred because immobilization of drug carrying particles at the mucosal surface would result in: A prolonged residence time at the site of action or absorption. A localization of the drug delivery system at a given target site. An increase in drug – concentration gradient due to intestine contact of the particles with the mucosal surface. A direct contact with intestinal cells, which is the step earlier to particle absorption. From past few years microparticles have been studied by many workers as a choice of sustained drug delivery system to provide a better drug bioavailability considering, high penetration property of the microparticles encapsulated agents through biological membrane and the stability of them. The present formulation study on Ciprofloxacin HCl is an attempt to prepare microparticle drug delivery system and evaluate its performance, In-vitro. The formulations were prepared, varying the ratios of polymer by emulsification solvent evaporation method. An ideal or best formulation of microparticles is the one which gives high entrapment efficiency along with good stability, retention time (by using HPLC) and drug release profile. In the present study entrapment efficiency is found to be drug and polymer ratio dependent. The release rate is found to be depended on polymer concentration. In the present study entrapment efficiency is found to be dependent on drug and polymer ratio. The formulation F1 (1:1), which showed higher entrapment efficiency and muco adhesive strength provides desired drug release rate. By these facts, study can be concluded by saying that Ciprofloxacin among the Mucoadhesive microspheres of Ciprofloxacin HCl prepared using Sodium CMC, Sodium Alginate, HPMC polymers using concentrations of 1:1 and 1:2 respectively, is a promising approach to enhancing the bioavailability of Ciprofloxacin HCl. The formulations F1, F2 showed reproducible results and the best Mucoadhesive profile with good surface morphology. The method employed gave spherical, discrete, and free flowing microspheres of Ciprofloxacin. Among all the formulations of microspheres, Sodium CMC with 1:1 praportions showed the best sustained release mucoadhesive effect