Synthesis, Antiinflammatory and Antimicrobial Activities of Newer Series of 1,3,4-Oxadiazoles.

The study of an antimicrobial agent is anything that can kill or inhibit the growth of bacteria such as high heat or radiation or a chemical substance. The antimicrobial agents are broadly classified into antibacterial, antifungal, antiviral, antiprotozoal, antiparasitic and anthelmintics. The antimicrobial agents act by interfering with cell wall synthesis, plasma membrane integrity, nucleic acid synthesis, ribosomal function and folate synthesis. Antibacterial agents are used in relatively low concentrations in or upon the bodies of organisms to prevent or treat specific bacterial diseases without harming the host organism. The most commonly used methods for determination of antimicrobial activity are cylinder plate or cup plate method, turbidimetric or tube assay method and disc diffusion method. Based on these reports, we have planned to synthesize the mannich bases of 1,3,4-oxadiazole derivatives and 2,5-disubstituted-1,3,4-oxadiazole derivatives and screen for antiinflammatory and antimicrobial activities. The 2,5-disubstituted-1,3,4-oxadiazoles and mannich bases of 1,3,4- oxadiazoles shown moderate antibacterial and antifungal activities. Among the ten compounds synthesized only two were tested for antiinflammatory activity and it could show significant action compared to the standard. Hence less information is obtained in terms of antiinflammatory action for the synthesized compounds. On antimicrobial screening, though the compounds could show activities against bacterial and fungal strains but it is less compared to standard. Further research is needed to correlate the 1,3,4-oxadiazole with its antiinflammatory and antimicrobial activities