A Validated Estimation of Ibuprofen and Famotidine in Pure and in Dosage form by UV Spectrophotometry and Rp-Hplc.

The present study contains Ibuprofen and Famotidine in solid oral dosage forms, recently this combination has been approved by CDSCO (Central Drug Standard Organisation) Literature survey reveals that UV, HPLC and GCmethods are reported for the determination of ibuprofen and famotidine individually and combination with some other drugs. There are no reported UV and RP-HPLC methods for simultaneous estimation of both drugs in combined dosage form. Hence an attempt has been made to develop simple sensitive, rapid, accurate and precise for the simultaneous estimation of ibuprofen and famotidine in bulk and in tablet dosage form. Ibuprofen is chemically (RS) – 2 – (4-(2- methyl propyl) Phenyl) propanoic acid1. It is a nonsteroidal anti – inflammatory drug (NSAID) used for relief of symptoms’ of arthritis, fever and analgesic (pain reliever) especially where there is an inflammatory component and dysmenorrhea. Famotidine is chemically 3 – [[[2-(Diaminomethylen] amino ] thiazol – 4 – yl] methyl]sulphanyl N – sulphamoyl propanimidamide1. It is a histamine H2 – receptor antagonist that inhibits stomach acid production, and it is commonly used in the treatment of peptic ulcer diseases and gastroesophageal reflux disease. Combination of ibuprofen and famotidine is anti inflammatory and reduce the risk of ulcer. The proposed analytical methods are simple, economical, rapid, sensitive, reproducible and accurate for the simultaneous estimation of ibuprofen and famotidine. The methods adopted for studies findings would be helpful to the analytical chemists to apply the analytical methods for the routine analysis of the analyte in pharmaceutical dosage forms after their approval from FD