Method Development and Method Validation for the Estimation of Tolterodine Tartrate in Tablet Dosage form by RP-HPLC.

Analytical chemistry is a scientific discipline used to study the chemical composition, structure and behaviour of matter. The purpose of this is to gather and interpret chemical information that will be of value to society in a wide range of contexts. Any chemical analysis can be broken down into a number of stages that include a consideration of the purpose of the analysis, the quality of the results required and the individual steps in the overall analytical procedure. Analytical procedure summarized by the following steps. The developed chromatographic method for the determination of test procedure of assay for Tolterodine tartrate in pharmaceutical dosage forms were simple, reliable, sensitive and less time consuming. The advantage of the present test procedures was that it does not require any complicated mobile phase and it is simple isocratic method. The present method can be confidently used for rapid and precise quantitation of Tolterodine tartrate. This procedure can be a major interest in analytical pharmacy, since it offers a distinct quality control in the test procedure of assay of pharmaceutical dosage forms. However taking into account of the factors such as economy and rapidity, the present method can also be a good choice for the analysis of Tolterodine tartrate. The developed method may be recommended for routine and quality control analysis of the investigated drug. The present work shows, a validated, highly sensitive and selected method for the determination of Tolterodine tartrate in pharmaceutical dosage forms. Precision and accuracy as major control parameters of the whole validation procedure was within the acceptable limits. The experimental data makes a relevant contribution to the understanding of validation parameters. Overall the above developed analytical method represents a valuable data for the validation of Tolterodine tartrate tablets and rapid quantitation method for the same in the pharmaceutical dosage forms