Effect of Courouptia Guianensis on N-Diethylnitrosamine Induced Oxidative Stress in Wistar Rats.

The present study shows that the Couroupita guianensis flower extract exhibits excellent hepatoprotective property by restoring the hepatic marker enzymes and by stabilizing and increasing all the components of antioxidant defense system during diethylnitrosamine induced oxidative stress in rats. I suggest that the natural antioxidants and scavenging agents in Couroupita guianensis flower extract might be effective as hepatoprotectors and thus, may have some obvious therapeutic implications. Therefore, it seems logical to infer that Couroupita guianensis flowers, because of its antioxidant property, might be capable of protecting the hepatic tissue from diethylnitrosamine-induced injury. The ethanol extract of Couroupita guianensis flower extract is found to be rich in flavonoids, phenolics and tannins in our preliminary photochemical screening. Since flavonoids, phenolics and tannins are powerful antioxidants, their presence in Couroupita guianensis flower extract flower extract might be responsible for antioxidant property, which might be involved in the hepatoprotective activity