Effect of Aqueous Extract of Cyperus Rotundus Roots on Diabetic Complications in Alloxan Induced Diabetic Rats.

Diabetes is a multifarious group of disorders characterized by hyperglycemia that has reached epidemic proportions in the current century. Infection is a leading cause of morbidity and mortality among the diabetic population. Diabetes is involved with vascular and renal damage characterized by hypertension, dyslipidemia, micro-albuminuria, macro-albuminuria and glomerular mesangial rise5. Diabetes mellitus may present with characteristic symptoms such as polyphagia, polydypsia, polyuria, blurring of vision, and weight loss. In its severe forms, ketoacidosis or a non-ketonic hyperosmolar state may develop and lead to stupor, coma and in the absence of effective treatment to death, oral administration of aqueous extract of cyperus rotundus. exhibit, Neuroprotective, nephroprotective and hepatoprotective activities via enhancing insulin production and decreasing glucogan production and decreasing a SGOT snd SGPT level in alloxan induced diabetic rats. Thus, oral use of this extract might positively affect the functional capacities of various rat tissues, particularly blood, kidney , liver and nerves against toxic action of alloxan compound (dose of 150 mg/Kg bw). These findings clearly support the traditional use of this medicinal plant in treatment of diabetes mellitus and complications shed more light in the efficacy of this plant. Thus, Cyperus rotundus appears to a valuable plant and ideally suited to be used in treatment of DM and prevent or delay the onset of its complications in humans, since this is a nontoxic plant