Formulation Development and Evaluation of Rosuvastatin Calcium Controlled Release Effervescent Floating Matrix Tablets (Grdds)

The oral route is the most preferred route of administration of drugs because of low cost of therapy, ease of administration, patient compliance and flexibility in formulation etc. During the past few decades, numerous oral drug delivery systems have been developed to act as drug reservoirs from which the active substance can be released over a specific period of time at a predetermined and controlled rate. It is evident from the recent scientific and patent literatures that an increased interest in novel oral controlled release dosage forms that designed to be retained in the Gastro Intestinal Tract (GIT) for a prolonged and predictable period of time exists today. Several approaches are currently utilized in the prolongation of the Gastric Residence Times (GRT) , including Floating Drug Delivery Systems (FDDS), Low- density Systems, Raft Systems incorporating Alginate gels, Bioadhesive or Mucoadhesive Systems, High-density Systems, Super porous Hydrogels and Magnetic systems. The current review addresses briefly about the FDDS that is one of the most leading methodologies in Gastro Retentive Drug Formulations. The Rosuvastatin Calcium Floating matrix tablets were prepared and evaluated. The Gastric Residence Time (GRT) of the tablet was considerably increased up to 24hrs time by optimizing the polymer concentration. The release was sustained up to 20hrs with 1: 1.5 ratio of HPMC K4M and Xanthan gum, but the Floating Lag time was found to be more with the combination. Similarly, the combination between HPMC K4M and Guar gum also controlled the release more than 20hrs was observed. The combination between HPMC K100M and Carbopol 934P with the ratio of 2:1 was found to be satisfactory with release profile. Hence the Formulation F10 was optimized by for further studies. The formulation (F10) also satisfies the Swelling Index, Buoyancy time controlled the drug release up to 24hrs. The mechanism of drug release followed the Zero order kinetics with the co-efficient (R2) value 0.996. Therefore, further studies with optimized formulation under progress in the lab