In-Vitro Dissolution and In-Vivo Bioavailability of a Novel Solid Dispersion of Losartan Potassium and Hydrochlorothiazide.

The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects of drug development. Although salt formation, solubilization, and particle size reduction have commonly been used to increase dissolution rate and thereby oral absorption and bioavailability of such drugs,1 there are practical limitations of these techniques. The present study shows improved dissolution and pharmacokinetics of HCT from a modified novel drug-drug solid dispersion. _ Dissolution and pharmacokinetics of HCT was better from HCT-LSP solid dispersion as compared to physical mixture and commercial product. This novel solid dispersion is stable as no physiological inert carriers that are affected by moisture are used. Cost effective and economical as this approach is free of the economical burden of physiological inert carriers. Further studies in humans are recommended to address the therapeutic advantages of the novel solid dispersion in clinical practice