Formulation and Evaluation of Gelatin Microspheres Loaded with Lisinopril Dihydrate.

For many decades, medications of an acute disease or a chronic illness has been accomplished by delivering drugs to the patients via various pharmaceutical dosage forms like tablets, capsules, pills, creams, ointments, liquids, aerosols, injectables and suppositories as carriers. To achieve and then to maintain the concentration of drug administered within the therapeutically effective range needed for medication, it is often necessary to take this type of drug delivery systems several times a day. This results in a fluctuated drug level and consequently undesirable toxicity and poor efficiency. The Micro encapsulation of Lisinopril Dihydrate with gelatin, gelatin –carbopol and gelatin-Sodium alginate by co-acervation phase separation technique utilizing temperature change and cross linking with formaldehyde, was able to sustain the drug release efficacy. The microspheres having gelatine-sodium alginate and gelatin-carbopol polymers mixtures (F6&F3) provides the best sustained release formulations and other formulations (F1, F2) may be suitable for prolonged action formulations. These studies compared the release behaviour of gelatin, gelatin-sodium alginate and gelatin –carbopol controlled release system of Lisinopril microspheres. The F3 & F6 formulations had more pronounced controlled release effects compared with other formulations