Formulation and Evaluation of Bilayer Tablets of Metformin Hydrochloride SR and Vildagliptin IR

Diabetes is a chronic disease in which body does not make or properly use insulin, a hormone that is needed to convert glucose and other food in to energy. Diabetes ellitus, describes a group of metabolic diseases in which the person has high blood glucose (blood sugar), either because insulin production is inadequate, or because the body's cells do not respond properly to insulin, or both. Patients with high blood sugar will typically experience polyuria (frequent urination), they will become increasingly thirsty (polydipsia) and hungry (polyphagia). The release of Metformin Hydro Chloride was found to follow matrix diffusion as evidenced by the linear cumulative % of drug release vs log cumulative % of drug release. The present study resulted in a successful development of a formulation for once a day dosage form containing Metformin HCI SR in one layer and Vildagliptin IR in another layer