Evaluation of Oxidative Stress in the Pathogenesis of Preeclampsia by Studying the Changes in Plasma Malondialdehyde and Ceruloplasmin.

Preeclampsia is a human pregnancy specific, multi system disorder that Is characterized by hypertension and proteinuria1. Inspite of intensive effort to Identify the pathophysiological mechanism neither a specific cause nor a Pathogenesis has been identified. Roes, EM et al.hypothesised that endothelial dysfunction plays a major Role in preeclampsia2. Carl A. Hubel reviewed the role of oxidative stress in vascular Endothelial cell damage and also recorded increased level of lipid peroxidation Products in preeclampsia3. Atamer Y et al. Reported that the plasma antioxidant activity in Preeclampsia is defective, and could be the causative factor that is responsible For endothelial damage4. Gutteridge JMC et al. Reported that Ceruloplasmin is the major plasma Antioxidant and its activity is found to decrease in preeclampsia5. The increased Lipid peroxidation along with decreased ceruloplasmin activity may play a role In pathogenesis of preeclampsia.6 The present study was carried out to determine the level of plasma, Malondialdehyde [MDA] as a marker of lipidperoxidation and ceruloplasmin as An antioxidant against lipid peroxidation. By performing the above parameters In preeclampsia the antioxidant status and oxidative stress were studied