Developmental Studies of Cefazolin Loaded Bovine Serum Albumin Nanoparticles.

Nanotechnology can be defined as the science and engineering involved in the design, synthesis, characterization and application of materials and devices, whose smallest functional organization in atleast one dimension is on the nanometer scale (one billionth of a meter). It can prove to be a boon for human health care. Because nano science and nanotechnology have a huge potential to bring benefits in areas as diverse as drug development, water decontamination , information and communication technologies and production of stronger /lighter materials. Human health nanotechnology research can definitely result in immense health benefits. The genesis of nanotechnology can be traced to the promise of revolutionary advances across medicines, communications, genomics and robotics. Hence, Cefazolin loaded albumin nanoparticles can be successfully prepared by coacervation following crosslinking with glutaraldehyde. The characterizations of the resulting nanoparticles were dependent on the polymer concentration, pH and the rpmof thestirrer during the desolvating process. And number of variables which might affect the final nanoparticle size was investigated to optimize the formulation.The preparation process of BSA nanoparticles was optimized by varying various parameter pH(8-10),polymer concentration (1%-3%) and rpm of the stirrer (1000,500), wherein pH 8, 1% polymer concentration and 1000rpm were found to be most favorable. The invitro release studies indicated there was an initial burst release of the drug in 0.5 hours followed by sustained release for 12 hours. According to the literature, the results demonstrated that produced nanoparticles have sufficient properties as a carrier for drug delivery systems