Design and Development of Colon Specific Delivery Systems of Aceclofenac Tablet

The various routes of administration, the oral route is considered to be most convenient for the administration of drugs to patients. On oral administration of conventional dosage forms drug normally dissolves in the gastro-intestinal fluids and is absorbed from regions of the gastro-intestinal tract, which depends upon the physicochemical properties of the drug. It has a serious drawback in conditions where localized delivery of the drug in the colon is required or in conditions where a drug needs to be protected from the hostile environment of upper GIT. Dosage forms that deliver drugs in the colon rather than upper GIT has number of advantages. Among the various routes of administration, the oral route is considered to be most convenient for the administration of drugs to patients. On oral administration of conventional dosage forms drug normally dissolves in the gastro-intestinal fluids and is absorbed from regions of the gastro-intestinal tract, which depends upon the physicochemical properties of the drug. It has a serious drawback in conditions where localized delivery of the drug in the colon is required or in conditions where a drug needs to be protected from the hostile environment of upper GIT. Dosage forms that deliver drugs in the colon rather than upper GIT has number of advantages