Clinicopathological, Histomorphological and Immunohistochemical study of Neuroendocrine Tumors of GIT.

Neuroendocrine tumors are relatively rare neoplasms that arise in various organs and share many common pathological features. In the year 2010 WHO graded Neuroendocrine tumors based on mitotic rate and Ki-67 index into NET G1, NET G2, NET G3 and Mixed adenoneuroendocrine carcinomas. The objectives of this study were to evaluate clinicopathological, histomorphological and immunohistochemical features of neuroendocrine tumors of the gastrointestinal tract. In this study, a total of 53 specimens received between 2008 and 2012 diagnosed as having neuroendocrine tumors of GIT were analysed for histopathological and immunohistochemical expression. Results: In our study neuroendocrine tumors of git were more common in males. The most common anatomical location was stomach. The median age at diagnosis was fifty. Most of the tumors were NET G1.We found MANEC to have a higher incidence. The positivity rates for NSE, Synaptophysin and chromogranin A was 97.5%, 87.5% and 82.5% respectively. Conclusion: The incidence of neuroendocrine tumors is on the rise. Immunohistochemical confirmation of histopathological diagnosis is important to distinguish NETs from other neoplasms and to give a definitive diagnosis