Histopathological Evaluation of Renal Biopsies In Cases of Nephrotic Syndrome with Special Reference to Use of Immunofluorescent Staining in Selected Cases.

The Diseases Of The Kidney Are Fascinating Which Can Have Varied Of Clinical Presentations, With No Two Patients Being Alike. In Our Country, Renal Diseases Form An Important Cause For Morbidity And Mortality. Nephrotic Syndrome Is An Important And Common Clinical Presentation. The Causes Of Nephrotic Syndrome Are Numerous, Which Can Be Either Primary Or Secondary. Once The Secondary Forms Of Nephrotic Syndrome Are Excluded By Appropriate Clinical And Laboratory Data, There Remains A Group Of Patient With Idiopathic Nephrotic Syndrome Who Can Be Precisely Differentiated Only By Renal Biopsy. In Children With Idiopathic Nephrotic Syndrome, Empirical Steroid Therapy Is The Initial Treatment Of Choice. However In Children Who Fail To Respond To A Course Of Steroids, Renal Biopsy May Be Indicated, To Provide A Specific Diagnosis. The Primary Role Of Renal Biopsy Is To Provide A Definite Diagnosis That Allows The Clinician To Assign Lesion – Specific Therapy. There Has Been Tremendous Growth In The Field Of Immunology, Especially Pertaining To Nephrology, Which Is Useful In The Clinical Diagnosis Of The Condition, Helpful To Prognosticate And Predict Therapeutic Response. The Present Study Has Been Taken–Up With An Earnest Attempt To Find Out The Common Histopathological Patterns Of Renal Diseases Which Clinically Present With Features Of Nephrotic Syndrom