Analysis of Fibreoptic Lung Biopsy Specimens Regarding Demographic Characteristics, Histologic Types and With Reference to Immunohistochemistry (P63).

Lung Cancer Ranks Among The Most Common And Most Lethal Malignancies Worldwide. It Is Rapidly Emerging As A Major Cause Of Mortality In The Middle East, Africa, And Asia As Well; And Is Increasingly Being Recognized In India[2]. Death Rates Attributable To This Disease Are Expected To Increase Substantially Over The Next Several Decades[3]. Procedures Used To Diagnose Bronchopulmonary Neoplasms Should Be As Accurate As Possible And Should Provide Optimum Characterization Of The Tumor Type. Fibreoptic Bronchoscopic Biopsy Refers To The Bronchoscopic Technique Of Obtaining Pulmonary Parenchymal Tissue For Histological Analysis. It Is One Of The Common Modality Used To Diagnose Lung Cancer And Is The Best Technique For Obtaining Specimens To Diagnose Endobronchial Lung Carcinoma. The Lesion Can Be Visualized And The Location Of The Specimen Can Be Mapped Precisely With A Fibreoptic Bronchoscope. The Histopathologic Distinction Of Small Cell From Non–Small Cell Carcinoma Of Lung Is Important Therapeutically. However, Such Distinction May Not Always Be Straightforward Based On Morphologic Findings Alone, Especially In Cytologic Specimens, But In Tissue Specimens As Well. P63 Is A Recently Discovered Member Of The P53 Family That Has Been Shown To Be Important In The Development Of Epithelial Tissues. P63 May Also Play A Role In Squamous Cell Carcinomas Of The Lung, Head And Neck, And Cervix, And Its Expression Is Increased In These Tumors[1]. The Purpose Of This Study Was To Analyse The Demographics, Risk Factors, Distribution Of Lung Carcinomas And To Investigate The Expression Of P63 In Various Histologic Types Of Lung Tumors And Correlate With Histological Gradings