Evaluation of Poly-MVA as a new radio-protectant against high LET particle irradiation

Ploy MVA was evaluated for its potential to protect mouse from radiation. Treatment of 8 Gy X-ray-irradiated mice with polyMVA increased survival rate to 100% 30 days after irradiation. The best effect was based on adequate absorption of ployMVA by a health mouse intestine. Doses higher than 8 Gy X-rays or 5.5 Gy carbon ions induce serious intestinal injury, which caused impedient absorption of ployMVA. We found simple ployMVA treatment was ineffective in protecting mice from carbon ion irradiation of doses higher than 5.5 Gy. However, the synergistic effect of ployMVA and Amifostine against irradiation deserves further exploration. In the FY 2018, we have plotted a credible survival fraction of the mice exposed to X-ray irradiation, which has laid the foundation for the heavy ion experiments.平成30年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告