Multimodal Thermo-Sensitive Polymer-Modified Liposome for Visualization and Treatment of Disseminated Cancer

A drug delivery system using a multimodal thermo-sensitive \u27polymer-modified\u27 liposome (MTPL) would be a powerful imaging tool to help avoid the side-effects of chemotherapy on the intact organ. In this study, an accumulation of and thermo-triggered drug release from MTPL were evaluated for disseminated-cancer using MRI and optical imaging. In the ex vivo optical images, the MTPL accumulation in the tumor area increased over 8 hours after the administration. In the T1-weighted MRI, the signal intensities in the bowel and the kidney changed after thermo-triggering.ISMRM 17th Scientific Meeting & Exhibitio