Measurement of Mn, Ni, Cu, Zn, As, Se, Mo and Pb in urine samples by octapole reaction system ICP-MS

Consumption of contaminated drinking water and foods with metals is of great concern from the viewpoint of public health. It is already known that a large-scale poisoning by arsenic (As) has become one of the major issues in developing countries mainly due to its high concentration in bedrocks. To evaluate metal concentration effects on human health, it is necessary to measure elemental concentrations in biological samples, such as urine. In this study, we used an octapole reaction system ICP-MS (ORS-ICP-MS) to measure Mn, Ni, Cu, Zn, As, Se, Mo and Pb in urine samples. We also measured river water samples for comparison. The ORS can be used to eliminate isobaric interferences by introducing H2 or He gas into the octapole reaction cell.Reference urine sample (NIES, No.18) were used to check applicability of ORS-ICP-MS for determination of these elements. The sample was diluted in 3.5% HNO3 solution and was directly measured by ORS-ICP-MS using the H2 gas mode for Mn, Zn, Se and Pb, and the He gas mode for Ni, Cu, As and Mo. The results demonstrated that the analytical results agreed well with the certified values within the error. Using this simple method, we measured concentrations of urine samples collected in Bangladesh.International Symposium on Metallomics 200