Structure-Activity Correlation in the Scavenging-Reaction of Cumylperoxyl Radical by Polyphenolic Flavones

The radical-scavenging activity of naturally occurring polyphenols, such as catechins, quercetin, resveratrol, and so on, has attracted considerable interest with regard to prevention of diseases induced by oxidative stress . However, very little is known about the structure?activity correlation in the radical-scavenging reactions by polyphenolic antioxidants. In this study, we examined the dynamics of the scavenging reaction of cumylperoxyl radical by four polyphenolic flavones, quercetin, luteolin, kaempferol, and apigenin, in propionitrile at 203 K by using the electron spin resonance (ESR) technique. The results obtained in this study suggest that not only the OH group at C-3\u27 position on the B ring but also that at C-3 position on the C ring plays an essential role in the radical-scavenging reaction.電子スピンサイエンス国際会議−第46回電子スピンサイエンス学会年会合同討論