Long-term Outcomes of Carbon-ion Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Uterine Cervix

Okonogi Noriyuki
Wakatsuki Masaru
Kato Shingo
Shiba Shintaro
Kobayashi Daijiro
Kiyohara Hiroki
Karasawa Kumiko
Ohno Tatsuya
Nakano Takashi
Kamada Tadashi
SHOZU MAKIO

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Publication date

January 2018

DOI

10.21873/anticanres.12244

Publisher

Anticancer Research USA Inc.

Journal

Anticancer Research

Abstract

Background/Aim: To evaluate the long-term outcomes of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical squamous cell carcinoma (LAC-SqCC) in 2 prospective phase I/II studies. Patients and Methods: In the first study, 14 patients were treated with 68.8-72.8 Gy (RBE)/24 fractions. In a subsequent study, 22 patients were treated with 64.0-72.0 Gy (RBE)/20 fractions while limiting the dose to the gastro-intestinal (GI) <60 Gy (RBE). Results: The 10-year local control rates were 92% and 61% for the patients administered a total dose of 72.0-72.8 Gy (RBE) and 64.0-68.8 Gy (RBE), respectively. Two patients in the first study developed grade 3/4 rectal or bladder complications; however, no grade 3 or higher complications occurred in...