Radiosynthesis, Photoisomerization, Biodistribution, and Metabolite Analysis of 11C-PBB3 as a Clinically Useful PET Probe for Imaging of Tau Pathology.
- Hashimoto Hiroki
- Kawamura Kazunori
- Igarashi Nobuyuki
- Takei Makoto
- Fujishiro Tomoya
- Aihara Yoshiharu
- Shiomi Satoshi
- Muto Masatoshi
- Ito Takehito
- Furutsuka Kenji
- Yamasaki Tomoteru
- Yui Joji
- Xie Lin
- Ono Maiko
- Hatori Akiko
- Nemoto Kazuyoshi
- Suhara Tetsuya
- Higuchi Makoto
- Zhang Ming-Rong
Publication date
June 2014
DOI Publisher
Society of Nuclear Medicine Journal
Journal of Nuclear MedicineAbstract
2-((1E,3E)-4-(6-((11)C-methylamino)pyridin-3-yl)buta-1,3-dienyl)benzo[d]thiazol-6-ol ((11)C-PBB3) is a clinically useful PET probe that we developed for in vivo imaging of tau pathology in the human brain. To ensure the availability of this probe among multiple PET facilities, in the present study we established protocols for the radiosynthesis and quality control of (11)C-PBB3 and for the characterization of its photoisomerization, biodistribution, and metabolism
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