The incorporation of halogenated pyrmidines such as bromo- and iodo-deoxyuridines (BrdU, IdU) into DNA as thymidine analogs enhances cellular radiosensitivity when high-linear energy transfer (LET) radiation is not used. Although it is known that high-LET ionizing radiation confers fewer biological effects resulting from halogenated pyrimidine incorporation, the exact mechanisms of reduced radiosensitivity with high-LET radiation are not clear. We investigated the radiosensitization effects of halogenated pyrimidines with high-LET radiation using accelerated carbon and iron ions. Cells synchronized into the G1 phase after unifilar (1 cell cycle) and bifilar (2 cell cycles) substitution with 10 µM BrdU were exposed to various degrees of LET ...
Lymphocytes are known to be sensitive to ionizing radiation, but the crucial factor causing this hyp...
Ionizing radiation produces various types of DNA lesions, such as base damage, single-strand breaks,...
The DNA double-strand break (DSB) is a critical lesion which, if not completely restored, can have s...
The incorporation of halogenated pyrmidines such as bromo- and iodo-deoxyuridines (BrdU, IdU) into D...
DNA double-strand breaks (DSBs) induced by ionizing radiation pose a major threat to cell survival. ...
High LET heavy ion radiation has been successfully used for radiation cancer therapy and the biologi...
Despite the efforts by many groups, photon-induced Auger effects of halogenated DNA have not shown u...
DNA double strand break (DSB) induced by ionizing radiation (IR) is a deleterious damage for cell su...
DNA is the critical target when cells are exposed to ionizing radiation, a potent stressor with capa...
Ionizing radiation induces a variety of DNA lesions such as base damage, single-strand breaks (SSBs)...
Heavy ion particles are one of the critical components in space radiation. These are classified as h...
The thymidine analogue, 5’-bromodeoxyuridine (BrdU), is a known mutagen that is routinely introduced...
Ionizing radiation is frequently used to kill tumor cells. However, hypoxic solid tumor cells are mo...
DNA double strand break (DSB) induced by ionizing radiation (IR) is a deleterious damage for cell su...
High LET heavy ion radiation has been successfully used for an alternative radiation treatment for c...
Lymphocytes are known to be sensitive to ionizing radiation, but the crucial factor causing this hyp...
Ionizing radiation produces various types of DNA lesions, such as base damage, single-strand breaks,...
The DNA double-strand break (DSB) is a critical lesion which, if not completely restored, can have s...
The incorporation of halogenated pyrmidines such as bromo- and iodo-deoxyuridines (BrdU, IdU) into D...
DNA double-strand breaks (DSBs) induced by ionizing radiation pose a major threat to cell survival. ...
High LET heavy ion radiation has been successfully used for radiation cancer therapy and the biologi...
Despite the efforts by many groups, photon-induced Auger effects of halogenated DNA have not shown u...
DNA double strand break (DSB) induced by ionizing radiation (IR) is a deleterious damage for cell su...
DNA is the critical target when cells are exposed to ionizing radiation, a potent stressor with capa...
Ionizing radiation induces a variety of DNA lesions such as base damage, single-strand breaks (SSBs)...
Heavy ion particles are one of the critical components in space radiation. These are classified as h...
The thymidine analogue, 5’-bromodeoxyuridine (BrdU), is a known mutagen that is routinely introduced...
Ionizing radiation is frequently used to kill tumor cells. However, hypoxic solid tumor cells are mo...
DNA double strand break (DSB) induced by ionizing radiation (IR) is a deleterious damage for cell su...
High LET heavy ion radiation has been successfully used for an alternative radiation treatment for c...
Lymphocytes are known to be sensitive to ionizing radiation, but the crucial factor causing this hyp...
Ionizing radiation produces various types of DNA lesions, such as base damage, single-strand breaks,...
The DNA double-strand break (DSB) is a critical lesion which, if not completely restored, can have s...