The mapping of genes which affect individual cancer risk is an important but complex challenge. A surrogate assay of susceptibility to radiation-induced acute myeloid leukaemia(AML) in the mouse based on chromosomal radiosensitivity has been developed and validated. This assay was applied to the mapping of radiation-induced AML risk modifier loci by association with microsatellite markers. A region on chromosome (chr) 18 with strong association is identified and confirmed by backcross analysis. Additional loci on chrs 8 and 13 show significant association. A key candidate gene Rbbp8 on chr18 is identified. Rbbp8 is shown to be upregulated in response to X-irradiation in the AML sensitive CBA strain but not AML resistant C57BL/6 strain. This...
Secondary malignancies are a serious adverse consequence of alkylator chemotherapy. The risk of deve...
Exposure to ionizing radiation is considered by NASA to be a major health hazard for deep space expl...
Aim: Although acute myelogenous leukemia (AML) arising after radiation exposure is considered to be ...
The mapping of genes which affect individual cancer risk is an important but complex challenge. A su...
CBA/H inbred mice are susceptible to radiation-induced acute myeloid leukaemia (r-AML) while C57BL/6...
Studies of r-AML susceptible CBA/H and r-AML resistant C57BL/6 inbred mice have provided an animal m...
Exposure to ionizing radiation increases the incidence of acute myeloid leukemia (AML), which has be...
2010 Spring.Includes bibliographic references.Covers not scanned.Print version deaccessioned 2022.Ac...
Ionising radiation is a carcinogen capable of inducing tumours, including colorectal cancer, in both...
Ionising radiation is a carcinogen capable of inducing tumours, including colorectal cancer, in both...
To determine the genetic characteristics of individual patients and their cancers for more effective...
The use of radiation therapy is a cornerstone of modern cancer treatment. The number of patients tha...
This review assesses recent data on mutational risk to the germline after radiation exposure obtaine...
OBJECTIVE: High-dose radiation exposure induces acute myeloid leukemia (AML) in C3H mice, most of wh...
Hematologic toxicity is a common side effect of multimodal cancer therapy. Nearly all animal studies...
Secondary malignancies are a serious adverse consequence of alkylator chemotherapy. The risk of deve...
Exposure to ionizing radiation is considered by NASA to be a major health hazard for deep space expl...
Aim: Although acute myelogenous leukemia (AML) arising after radiation exposure is considered to be ...
The mapping of genes which affect individual cancer risk is an important but complex challenge. A su...
CBA/H inbred mice are susceptible to radiation-induced acute myeloid leukaemia (r-AML) while C57BL/6...
Studies of r-AML susceptible CBA/H and r-AML resistant C57BL/6 inbred mice have provided an animal m...
Exposure to ionizing radiation increases the incidence of acute myeloid leukemia (AML), which has be...
2010 Spring.Includes bibliographic references.Covers not scanned.Print version deaccessioned 2022.Ac...
Ionising radiation is a carcinogen capable of inducing tumours, including colorectal cancer, in both...
Ionising radiation is a carcinogen capable of inducing tumours, including colorectal cancer, in both...
To determine the genetic characteristics of individual patients and their cancers for more effective...
The use of radiation therapy is a cornerstone of modern cancer treatment. The number of patients tha...
This review assesses recent data on mutational risk to the germline after radiation exposure obtaine...
OBJECTIVE: High-dose radiation exposure induces acute myeloid leukemia (AML) in C3H mice, most of wh...
Hematologic toxicity is a common side effect of multimodal cancer therapy. Nearly all animal studies...
Secondary malignancies are a serious adverse consequence of alkylator chemotherapy. The risk of deve...
Exposure to ionizing radiation is considered by NASA to be a major health hazard for deep space expl...
Aim: Although acute myelogenous leukemia (AML) arising after radiation exposure is considered to be ...