Add to ORKGWe evaluated the potential of[11C]MPDX as a radioligand for mapping adenosine A1 receptors in comparison with previously proposed[11C]KF15372 in cat brain by PET, Two tracers showed the same brain distribution. Brain uptake of[11C]MPDX (Ki=4.2nM)was much higher and washed out faster than that of[11C]KF15372 (Ki=3.0nM),and was blocked by carrier-loading or displaced with an A1 antagonist. The regional A1 receptor distribution evaluated with kinetic analysis is consistent with that previously measured in vitro.[11C]MPDX PET has a potential for mapping adenosine A1 receptors in brain
Adenosine A2A receptor (A2AR) is thought to interact with dopamine D2 receptor. Selective A2AR antag...
Purpose: [7-methyl-11C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX) is a pos...
Over the last decades adenosine receptor ligands, agonists as well as antagonists, have been develop...
BACKGROUND: Adenosine A1 receptors (A1Rs) in human and rodent brains can be visualized with the radi...
The important roles played by the A(1) adenosine receptor (A(1)AR) in brain physiology and pathology...
Adenosine is an endogenous modulator of several physiological functions in the central nervous syste...
Activation of adenosine A1 receptors (A1R) in the brain causes sedation, reduces anxiety, inhibits s...
Activation of adenosine A(1) receptors (A(1)R) in the brain causes sedation, reduces anxiety, inhibi...
PurposeThe A1AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([18F]CPFPX) has recent...
In vivo imaging of the A1 adenosine receptor (A1AR) using (18)F-8-cyclopentyl-3-(3-fluoropropyl)-1-p...
We examined whether measurement of the adenosine A1 recep-tor (A1-R) with PET can predict the severi...
Activation of adenosine A(1) receptors (A(1)R) in the brain causes sedation, reduces anxiety, inhibi...
Activation of adenosine A(1) receptors (A(1)R) in the brain causes sedation, reduces anxiety, inhibi...
Adenosine is an important neuromodulator. Basic cerebral effects of adenosine are exerted by the A1 ...
This thesis describes the development and evaluation of [11C]preladenant as a novel radioligand for ...
Adenosine A2A receptor (A2AR) is thought to interact with dopamine D2 receptor. Selective A2AR antag...
Purpose: [7-methyl-11C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX) is a pos...
Over the last decades adenosine receptor ligands, agonists as well as antagonists, have been develop...
BACKGROUND: Adenosine A1 receptors (A1Rs) in human and rodent brains can be visualized with the radi...
The important roles played by the A(1) adenosine receptor (A(1)AR) in brain physiology and pathology...
Adenosine is an endogenous modulator of several physiological functions in the central nervous syste...
Activation of adenosine A1 receptors (A1R) in the brain causes sedation, reduces anxiety, inhibits s...
Activation of adenosine A(1) receptors (A(1)R) in the brain causes sedation, reduces anxiety, inhibi...
PurposeThe A1AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([18F]CPFPX) has recent...
In vivo imaging of the A1 adenosine receptor (A1AR) using (18)F-8-cyclopentyl-3-(3-fluoropropyl)-1-p...
We examined whether measurement of the adenosine A1 recep-tor (A1-R) with PET can predict the severi...
Activation of adenosine A(1) receptors (A(1)R) in the brain causes sedation, reduces anxiety, inhibi...
Activation of adenosine A(1) receptors (A(1)R) in the brain causes sedation, reduces anxiety, inhibi...
Adenosine is an important neuromodulator. Basic cerebral effects of adenosine are exerted by the A1 ...
This thesis describes the development and evaluation of [11C]preladenant as a novel radioligand for ...
Adenosine A2A receptor (A2AR) is thought to interact with dopamine D2 receptor. Selective A2AR antag...
Purpose: [7-methyl-11C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX) is a pos...
Over the last decades adenosine receptor ligands, agonists as well as antagonists, have been develop...