Prediction of intestinal damage in neonates with gastroschisis

Prediction of intestinal damage in neonates with gastroschisis MUDr. Frýbová Barbora Objective: The aim of the study was to identify both prenatal ultrasonographic markers in fetuses and a biochemical marker in newborns with gastroschisis that predict postnatal outcome; to perform a new technique of defect closure by preformed silicone silo for gastroschisis and to evaluate long-term quality of life and somatic growth of patients with gastroschisis and compare them with the general population. Material and Methods: The analysis of 122 patients with gastroschisis operated on between 2004-2018 at the Department of Paediatric Surgery of University Hospital Motol in Prague was performed. In the retrospective-prospective study (97 patients) ultrasound findings at the 30th week of pregnancy and medical reports were statistically analyzed to identify independent prenatal ultrasonographic predictors of postnatal outcome. In the prospective study, new surgical technique of preformed silicone silo for gastroschisis to perform the stepwise defect reconstruction was used in four patients. In the prospective I-FABP study (53 patients), the urine was collected during the first 48 hours after surgery from neonates operated on for GS. Neonates with surgery that did not include gut mucosa served as controls for..