Monoclonal gamopathy

Charles University, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Study program: Medical Laboratory Technician Candidate: Eva Semerádová Thesis supervisor: Prof. PharmDr. Petr Nachtigal, Ph.D. Consultant: Jana Šimková, MSc. Title of bachelor thesis: Monoclonal gammopathy The aim of this thesis is to describe monoclonal gammopathy (MG) The bachelor thesis describes forms of this disease, its history, classification and variants of laboratory diagnosis. Interesting. Monoclonal gammopathy is characterized by the presence of monoclonal immunoglobulin in serum or urine. There are two main types of the disease - malignant monoclonal gammopathy (MMG) and monoclonal gammopathy of undetermined significance (MGUS). For the diagnosis of MG is essential to determine the presence of monoclonal immunoglobulin in serum or urine and to determine the extent of bone marrow lesion. Based on the risk factors (radiation, chemical carcinogens, genetic predisposition, virus dual intervention-theory) were taken into diagnostic tests as well those describing free light chains ratio, number of malignant cells and quantity of monoclonal immunoglobulin. The most commonly used diagnostic methods are electrophoretic methods because of their time- and cost-effectiveness. For the typing is..