Breast cancer (BC) is classified into four major molecular subtypes. The most predominant subtypes, luminal A and B are hormone receptor-positive BC (ERα +/PR+) which accounts for over 70% of BC cases. ERα +/PR+ breast cancers are treated with selective estrogen-receptor modulators such as tamoxifen, directed against the main therapeutic target estrogen receptor α (ERα). Tumors with HER2+ amplification are targeted by monoclonal antibody trastuzumab which significantly contributes to better prognosis. Finally, Triple-negative breast cancer has no therapeutic target identified, leaving patients with chemotherapy as their main option. Despite the overall success of chemotherapy, endocrine therapy, and the use of monoclonal antibody, one of th...
Nuclear receptors (NR) act as an integrated conduit for environmental and hormonal signals to govern...
Breast cancer, one of the most common of all cancers, is diagnosed in over 1.5 million people world-...
Abstract Background Breast cancer (BC) is highly heterogeneous with ~ 60–70% of estrogen receptor po...
The nuclear receptor (NR) family of transcription factors is intimately associated with the developm...
The interaction between breast tumor epithelial and stromal cells is vital for initial and recurrent...
The Nuclear Receptor (NR) superfamily of transcription factors comprises 48 members, several of whic...
To identify biologically relevant groupings or clusters of nuclear receptors (NR) that are associate...
International audienceIn breast cancer (BC) epithelial cells, the mitogenic action of estradiol is t...
The function of the nuclear receptor (NR) in breast cancer progression has been investigated for dec...
International audienceIn breast cancer (BC) epithelial cells, the mitogenic action of estradiol is t...
Extreme heterogeneity of breast cancer (BC) is considered to be one of the reasons that affects the ...
SummaryIn breast cancer, nuclear receptors (NRs) play a prominent role in governing gene expression,...
In the United States in 2009, 192,370 women are expected to be diagnosed with invasive breast cancer...
Nuclear receptors form a unique class of phylogenetically con-served transcriptional regulators ( 1)...
There is emerging evidence asserting the importance of orphan nuclear receptors (ONRs) in cancer ini...
Nuclear receptors (NR) act as an integrated conduit for environmental and hormonal signals to govern...
Breast cancer, one of the most common of all cancers, is diagnosed in over 1.5 million people world-...
Abstract Background Breast cancer (BC) is highly heterogeneous with ~ 60–70% of estrogen receptor po...
The nuclear receptor (NR) family of transcription factors is intimately associated with the developm...
The interaction between breast tumor epithelial and stromal cells is vital for initial and recurrent...
The Nuclear Receptor (NR) superfamily of transcription factors comprises 48 members, several of whic...
To identify biologically relevant groupings or clusters of nuclear receptors (NR) that are associate...
International audienceIn breast cancer (BC) epithelial cells, the mitogenic action of estradiol is t...
The function of the nuclear receptor (NR) in breast cancer progression has been investigated for dec...
International audienceIn breast cancer (BC) epithelial cells, the mitogenic action of estradiol is t...
Extreme heterogeneity of breast cancer (BC) is considered to be one of the reasons that affects the ...
SummaryIn breast cancer, nuclear receptors (NRs) play a prominent role in governing gene expression,...
In the United States in 2009, 192,370 women are expected to be diagnosed with invasive breast cancer...
Nuclear receptors form a unique class of phylogenetically con-served transcriptional regulators ( 1)...
There is emerging evidence asserting the importance of orphan nuclear receptors (ONRs) in cancer ini...
Nuclear receptors (NR) act as an integrated conduit for environmental and hormonal signals to govern...
Breast cancer, one of the most common of all cancers, is diagnosed in over 1.5 million people world-...
Abstract Background Breast cancer (BC) is highly heterogeneous with ~ 60–70% of estrogen receptor po...