Acute Spinal Cord injury (SCI) refers to a traumatic insult to the spinal cord that can lead to either temporary or permanent loss of motor/sensory and autonomic functions, below the site of injury. Though extensive research is going on, there is yet no pharmacological therapy available for SCI. Riluzole, an FDA approved drug for the treatment of amyotrophic lateral sclerosis (ALS), had demonstrated enhanced tissue sparing and recovery of motor function in a rodent SCI model. Following this, a phase I trial was conducted and safety of riluzole was established in SCI patients. Preliminary assessments indicated that riluzole improved the motor outcome in cervical injured (Grade B) patients. However, high inter- subject variability in plasma ...
International audienceWHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Spinal muscular atrophy (SMA) i...
A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and ...
Amyotrophic lateral sclerosis (Lou Gehrig's disease) is a devastating neurodegenerative disorder for...
Acute Spinal Cord injury (SCI) is a complex disorder involving a sudden traumatic insult to the cord...
A prospective, multicenter phase I trial was undertaken by the North American Clinical Trials Networ...
Spinal cord injury (SCI) is a devastating event resulting in permanent loss of neurological function...
Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclero...
Riluzole is a sodium-glutamate antagonist that attenuates neurodegeneration in amyotrophic lateral s...
OnlinePublRiluzole is a sodium-glutamate antagonist that attenuates neurodegeneration in amyotrophic...
Glutamatergic excitotoxicity is the main factor affecting the formation of edema, ischemia with a sp...
Study Design:Systematic review.Objective:To evaluate the impact of riluzole on neurobehavioral outco...
BackgroundSatisfactory treatment is often lacking for spasticity, a highly prevalent motor disorder ...
BACKGROUND CONTEXT: Damage to the spinal cord can result in irreversible impairments or complete los...
AbstractCervical spinal cord injury (SCI) can result in devastating functional deficits that involve...
International audienceSatisfactory treatment is often lacking for spasticity, a highly prevalent mot...
International audienceWHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Spinal muscular atrophy (SMA) i...
A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and ...
Amyotrophic lateral sclerosis (Lou Gehrig's disease) is a devastating neurodegenerative disorder for...
Acute Spinal Cord injury (SCI) is a complex disorder involving a sudden traumatic insult to the cord...
A prospective, multicenter phase I trial was undertaken by the North American Clinical Trials Networ...
Spinal cord injury (SCI) is a devastating event resulting in permanent loss of neurological function...
Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclero...
Riluzole is a sodium-glutamate antagonist that attenuates neurodegeneration in amyotrophic lateral s...
OnlinePublRiluzole is a sodium-glutamate antagonist that attenuates neurodegeneration in amyotrophic...
Glutamatergic excitotoxicity is the main factor affecting the formation of edema, ischemia with a sp...
Study Design:Systematic review.Objective:To evaluate the impact of riluzole on neurobehavioral outco...
BackgroundSatisfactory treatment is often lacking for spasticity, a highly prevalent motor disorder ...
BACKGROUND CONTEXT: Damage to the spinal cord can result in irreversible impairments or complete los...
AbstractCervical spinal cord injury (SCI) can result in devastating functional deficits that involve...
International audienceSatisfactory treatment is often lacking for spasticity, a highly prevalent mot...
International audienceWHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Spinal muscular atrophy (SMA) i...
A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and ...
Amyotrophic lateral sclerosis (Lou Gehrig's disease) is a devastating neurodegenerative disorder for...