The efficiency gains of hospital mergers and acquisitions (M&As) are derived not only from the market, financial, and managerial synergies, but also from operational synergies in economies of scale, clinical standardizations, service line optimizations, and so forth. To understand the roles that operations characteristics, and operations strategy play in hospital acquisitions, this dissertation examines the direct effects of geographic proximity and the service overlap on an acquired hospital’s post-acquisition operational performance (i.e., cost and quality) and its post-acquisition service-mix changes. The dissertation presents the findings from two essays. The first essay examines whether acquisitions benefit hospitals in terms of co...