This study deals with the seismic fragility of elastic structural systems equipped with single concave sliding (friction pendulum system (FPS)) isolators considering different soil conditions. The behavior of these systems is analyzed by employing a two-degree-of-freedom model, whereas the FPS response is described by means of a velocity-dependent model. The uncertainty in the seismic inputs is taken into account by considering artificial seismic excitations modelled as timemodulated filtered Gaussian white noise random processes of different intensity within the power spectral density method. In particular, the filter parameters, which control the frequency content of the random excitations, are calibrated to describe stiff, medium and sof...