Electromagnetic compatibility (EMC) investigations often involve the assessment of whether signal integrity (SI) and radiated susceptibility (RS) in transmission lines comply with design margins and/or maximum levels provided by EMC regulations. Hence, worst-case analysis is a useful tool to flag potential problems in the early design stage. This paper presents a novel paradigm for the worst-case SI/RS analysis of single-wire transmission lines. The method is based on the theoretical framework of Taylor arithmetic, which represents each variable as a Taylor expansion, function of the selected design parameter, complemented by an interval remainder that encompasses all approximation and round-off errors in a conservative way. A suitable modi...