One stage osteochondral repair with cartilage fragments in a hybrid scaffold: rabbit and goat animal model

One-step techniques are a promising approach for cartilage repair. This study introduces a simple chondrocyte culturefree approach with autologous cartilage fragments loaded onto a mixed scaffold composed of high molecular weight hyaluronic acid derivative felt (Hyaff-11), injectable human fibrin glue (Tisseel) and autologous platelet-rich plasma (PRP). Nanoindentation of goat samples showed mechanical properties close to native goat-trochelarcartilage