Background: Tumor promoters enhance tumor yield in experimental animals without directly affecting the DNA of the cell. Promoters may play a role in the development of cancer, as humans are exposed to them in the environment. In work based on computer-assisted microscopy and sophisticated classification methods, we showed that cells could be classified by reference to a database of known normal and cancerous cell phenotypes. Promoters caused loss of properties specific to normal cells and gain of properties of cancer cells. Other compounds, including colchicine, had a similar effect. Colchicine given together with paclitaxel, however, caused cells to adopt properties of normal cells. This provided a rationale for tests of microtubule inhibi...
Colchicine, a natural product of Colchicum autumnae currently used for gout treatment, is a tubulin ...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
Previous work from this laboratory employed an assay for cell morphology, which is based on computer...
The tumor promoter, phorbol 12-myristate 13-acetate (PMA), enhances tumor yield through an epigeneti...
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing...
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing...
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing...
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing...
AbstractColchicine is a very cheap microtubule destabilizer. Because microtubules are an ideal targe...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
Several colchicine analogues in which the N-acetyl residue has been replaced by aliphatic, straight-...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
In this review, an attempt has been made to throw light on the mechanism of action of colchicine and...
Colchicine, a natural product of Colchicum autumnae currently used for gout treatment, is a tubulin ...
Colchicine, a natural product of Colchicum autumnae currently used for gout treatment, is a tubulin ...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
Previous work from this laboratory employed an assay for cell morphology, which is based on computer...
The tumor promoter, phorbol 12-myristate 13-acetate (PMA), enhances tumor yield through an epigeneti...
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing...
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing...
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing...
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing...
AbstractColchicine is a very cheap microtubule destabilizer. Because microtubules are an ideal targe...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
Several colchicine analogues in which the N-acetyl residue has been replaced by aliphatic, straight-...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
In this review, an attempt has been made to throw light on the mechanism of action of colchicine and...
Colchicine, a natural product of Colchicum autumnae currently used for gout treatment, is a tubulin ...
Colchicine, a natural product of Colchicum autumnae currently used for gout treatment, is a tubulin ...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...