Functional metal-organic frameworks applied in cancer diagnosis and therapy

Metal-organic frameworks (MOFs) are well-defined crystalline organometallic compounds produced by hydro-solvothermal synthesis. The forty generated nanostructures with carboxylate cluster as organic linkers were characterized using microscopic, spectroscopic and X-ray diffraction analysis to obtain phase, crystallinity, lattice parameters, bulk modules, and periodical arranged clusters of MOFs respectively. These fabricated MOFs displayed distinctive grain boundaries, well-developed reticulates and high potency against three model systems, gram-negative bacteria (Escherichia coli), human retinal pigment epithelium (RPE) cells, and Chinese hamster ovary cancer cell lines (CHO). Low minimal bactericidal concentration (10-15 ppm) and rapid disinfection (< 30 min) were found with E. Coli and MOFs, low effective dose at fifty percent survival (ED50) against CHO (< ED50 ~ < 20 ppm) and RPE cells (ED50 ~ 22 ppm) which provide a new avenue for MOFs applications in environmental or biomedical application