Synthesis, Characterization and Evaluation the Biological Activity of New Heterocycle Compounds Derived from 4-Aminoacetophenone

This research included the synthesis of new heterocycle compounds from 4-Aminoacetophenone as starting material via three deferent routs; the first one included the synthesis of N-Aacetophenone-1,2,3-triazole derivatives. At the second rout we prepared chalcones, which cyclized by reacting with thiourea and hydroxyl amine hydrochloride. The third rout included the reaction of starting material with 2-mercaptobenimidazole and 2-mercaptobenzthiozole. The structures of newly synthesized heterocyclic compounds established on the basis of their m.p, TLC, IR, UV-Vis, C.H.N. and 1H-NMR data. The results of antimicrobial activity of newly synthesized heterocyclic compounds showed that some of it have good antimicrobial activity when compared with standard antibiotic. Keywords: triazole, Chalcone, pyrimidine, oxazole, Antimicrobial activity