Air pollutant is one of the major health related risk today. The presence of air pollutants as atmospheric substances or energy in uncontrollable quantities and of unimaginable duration is liable to cause harm to life, damage to man-made materials and structures, or changes in the weather and climate. This paper attempts to explain air pollution upon human health from the primary source point of view. It also looked at the historical background of air pollution, the source, Nitrogen Oxide (NOx), Carbon monoxide (CO), Sulphur oxide (SOx), Particulate matter (PM10, PM2.5), Hydrocarbons (HCs) to the Health effects of primary air pollutants such as Cardiovascular disease (CVD), Cancer, Chronic obstructive pulmonary disease (COPD), Asthma, Ind...