Catfish (Clarias gariepinus) Oil Intervention and its Effect on Lipid Profile and MDA Levels of Hypercholesterolemic Male Sprague-Dawley Rats

Catfish oil,which is rich in essential fatty acids,can be utilized as an alternative supplement solution. The objective of this study was to analyze the effect of catfish oil intervention on the lipid profile and malondialdehyde (MDA) levels of hypercholesterolemic male Sprague-Dawley rats. Four treatments were applied in this study: negative control (A1), refined fish oil (A2), fish oil with omega-3 concentrates (A3), and fish oil with omega-3 concentrates and vitamin E (A4). The results showed that catfish oil tended to reduce cholesterol levels. Negative control group had the highest value of lipid profile (58.3±9.93 mg/dL) among other groups. All intervention groups had very low MDA values (A1: 0.616±0.071, A2: 0.835±0.223, A3: 0.832±0.160, A4: 0.702±0.113 nmol/L), indicating that their MDA values were still normal (<4nmol/L). Keywords: Catfish oil, Hypercholesterolemia, Lipid profile, Malondialdehyd