Polyherbal Therapies Attenuated Diabetes Induced Liver Damage

To evaluate glucose, liver function, lipid profile, urea, total protein, albumin, globulin and weight of liver tissues in diabetic rats. Thirteen groups of 6 rats each were used. Groups 1 and 2 Normal and Diabetic Control received 0.5 ml Dimethylsulphoxide; 3 and 4 received 5UI/Kg b.w insulin and 5mg/Kg b.w glibenclamide; 5, 6, 7 and 8 received 500 mg/Kg b.w of Vernonia amygdalina, Moringa oleifera, Gongronema latifolium and Ocimum gratissimum extracts respectively; 9, 10 and 11 received 250 mg/ Kg b.w of M. oleifera/V. amygdalina, M. oleifera/ G. latifolium and M. oleifera/O. gratissimum respectively; 12 received 166.66mg/kg b.w of V. amygdalina/ G. latifolium/ O. gratissimum while 13 received 125mg/kg b.w of all extracts. There was reduction in liver weight, glucose, lipid profile and urea in all treated groups. Total protein, albumin, globulin and HDL-cholesterol increased in the treatment groups. Polyherbal treatments are potent at attenuating diabetes induced liver damage. Keywords: Hepatoprotective, Moringa oleifera, Vernonia amygdalina, Gongronema latifolium, Ocimum gratissimu