In the current study hundred ten of Iraqi patients with colorectal tumors were studied to evaluate the expressionof wild BRAF and BRAFV600E using Tissue microarray-Immunohistochemisty (TMA-IHC) technique. Of them,Ninety cases had colorectal carcinoma, and twenty had benign tumors. A group of twenty cases of non-specificcolitis and other twenty colonic biopsies with no significant pathology were also studied. Results of the studydemonstrated that BRAF expression was positive in 86.7% of carcinoma cases, and there was significantdifferences (P=0.038) in the expression of BRAF within tumor stages. Whereas BRAFV600E expression wasnegative in groups of adenoma, colitis and cases with no significant pathology compared to carcinoma group inwhich 1...
International audienceThe BRAFV600E mutation confers worse prognosis to metastatic colorectal cancer...
Mutation of BRAF at the valine 600 residue occurs in approximately 10% of colorectal cancers, a grou...
BACKGROUND: BRAF is a member of RAF family of serine/threonine kinases and mediates cellular respons...
Aim: to compare the immunoexpression of BRAF V600E among stage of colorectal cancer. Methods: this w...
WOS: 000361049900012PubMed ID: 26359417Background/Aim: The murine sarcoma viral (V-Raf) oncogene hom...
The B-type Raf kinase (BRAF) V600E mutation is a well-established biomarker for poor prognosis in me...
Background Colorectal carcinoma is the third most commonly diagnosed cancer worldwide and many stud...
PURPOSE Our purpose was development and assessment of a BRAF-mutant gene expression signature for co...
Background BRAF mutation has been recognized as an important biomarker of colorectal cancer (CRC) fo...
BACKGROUND: While the negative prognostic role of BRAF V600E mutation in metastatic colorectal canc...
Different genetic aberrations of BRAF have been reported in various malignancies. BRAF is member of ...
The activating BRAF (V600) mutation is a well-established negative prognostic biomarker in metastati...
AIM: To evaluate the clinicopathological features of colorectal cancer (CRC) with a v-Raf murine sar...
Introduction: BRAF mutant colorectal cancer (BRAF MT CRC) is a unique category of colorectal tumour ...
Alterations in the RAS-RAF-MAP2K (MEK)-MAPK signaling pathway are major drivers in colon and rectal ...
International audienceThe BRAFV600E mutation confers worse prognosis to metastatic colorectal cancer...
Mutation of BRAF at the valine 600 residue occurs in approximately 10% of colorectal cancers, a grou...
BACKGROUND: BRAF is a member of RAF family of serine/threonine kinases and mediates cellular respons...
Aim: to compare the immunoexpression of BRAF V600E among stage of colorectal cancer. Methods: this w...
WOS: 000361049900012PubMed ID: 26359417Background/Aim: The murine sarcoma viral (V-Raf) oncogene hom...
The B-type Raf kinase (BRAF) V600E mutation is a well-established biomarker for poor prognosis in me...
Background Colorectal carcinoma is the third most commonly diagnosed cancer worldwide and many stud...
PURPOSE Our purpose was development and assessment of a BRAF-mutant gene expression signature for co...
Background BRAF mutation has been recognized as an important biomarker of colorectal cancer (CRC) fo...
BACKGROUND: While the negative prognostic role of BRAF V600E mutation in metastatic colorectal canc...
Different genetic aberrations of BRAF have been reported in various malignancies. BRAF is member of ...
The activating BRAF (V600) mutation is a well-established negative prognostic biomarker in metastati...
AIM: To evaluate the clinicopathological features of colorectal cancer (CRC) with a v-Raf murine sar...
Introduction: BRAF mutant colorectal cancer (BRAF MT CRC) is a unique category of colorectal tumour ...
Alterations in the RAS-RAF-MAP2K (MEK)-MAPK signaling pathway are major drivers in colon and rectal ...
International audienceThe BRAFV600E mutation confers worse prognosis to metastatic colorectal cancer...
Mutation of BRAF at the valine 600 residue occurs in approximately 10% of colorectal cancers, a grou...
BACKGROUND: BRAF is a member of RAF family of serine/threonine kinases and mediates cellular respons...