Metabolites linked to changes in choline kinase-α (CK-α) expression and drug resistance, which contribute to survival and autophagy mechanisms, are attractive targets for breast cancer therapies. We previously reported that autophagy played a causative role in driving tamoxifen (TAM) resistance of breast cancer cells (BCCs) and was also promoted by CK-α knockdown, resulting in the survival of TAM-resistant BCCs. There is no comparative study yet about the metabolites resulting from BCCs with TAM-resistance and CK-α knockdown. Therefore, the aim of this study was to explore the discriminant metabolic biomarkers responsible for TAM resistance as well as CK-α expression, which might be linked with autophagy through a protective role. A total o...
Deregulation of the cell cycle machinery is a hallmark of cancer, leading to aberrant proliferation ...
Background: Curcumin (CUR) has deserved extensive research due to its anti-inflammatory properties, ...
Contains fulltext : 153147.pdf (publisher's version ) (Open Access)Docetaxel is on...
Metabolites linked to changes in choline kinase-α (CK-α) expression and drug resistance, which contr...
Metabolites linked to changes in choline kinase-α (CK-α) expression and drug resistance, which contr...
<div><p>Choline kinase-α (Chk-α) and autophagy have gained much attention, as they relate to the dru...
Choline kinase-α (Chk-α) and autophagy have gained much attention, as they relate to the drug-resist...
Breast cancer is a heterogeneous disease, and the survival rate of patients with breast cancer stron...
International audienceBreast cancer (BC) is one of the most common female cancers in the world, with...
<p>(A) RT-PCR analysis of Chk-α and β in MCF-7 and MCF-7/TAM cells. The level of Chk-α mRNA was high...
Here, we identified two new molecular targets, which are functionally sufficientto metabolically con...
The Warburg effect is a well-known phenomenon in cancer, but the glutamine addiction in which cancer...
BACKGROUND: Curcumin (CUR) has deserved extensive research due to its anti-inflammatory properties, ...
INTRODUCTION: The aim of this study was to investigate the differential expression of markers relate...
Metabolomic strategies have been extensively used to search for biomarkers of disease, including ca...
Deregulation of the cell cycle machinery is a hallmark of cancer, leading to aberrant proliferation ...
Background: Curcumin (CUR) has deserved extensive research due to its anti-inflammatory properties, ...
Contains fulltext : 153147.pdf (publisher's version ) (Open Access)Docetaxel is on...
Metabolites linked to changes in choline kinase-α (CK-α) expression and drug resistance, which contr...
Metabolites linked to changes in choline kinase-α (CK-α) expression and drug resistance, which contr...
<div><p>Choline kinase-α (Chk-α) and autophagy have gained much attention, as they relate to the dru...
Choline kinase-α (Chk-α) and autophagy have gained much attention, as they relate to the drug-resist...
Breast cancer is a heterogeneous disease, and the survival rate of patients with breast cancer stron...
International audienceBreast cancer (BC) is one of the most common female cancers in the world, with...
<p>(A) RT-PCR analysis of Chk-α and β in MCF-7 and MCF-7/TAM cells. The level of Chk-α mRNA was high...
Here, we identified two new molecular targets, which are functionally sufficientto metabolically con...
The Warburg effect is a well-known phenomenon in cancer, but the glutamine addiction in which cancer...
BACKGROUND: Curcumin (CUR) has deserved extensive research due to its anti-inflammatory properties, ...
INTRODUCTION: The aim of this study was to investigate the differential expression of markers relate...
Metabolomic strategies have been extensively used to search for biomarkers of disease, including ca...
Deregulation of the cell cycle machinery is a hallmark of cancer, leading to aberrant proliferation ...
Background: Curcumin (CUR) has deserved extensive research due to its anti-inflammatory properties, ...
Contains fulltext : 153147.pdf (publisher's version ) (Open Access)Docetaxel is on...