Estimating the age and strength of beneficial alleles is central to understanding how adaptation proceeds in response to changing environmental conditions. Several haplotype-based estimators exist for inferring the age of segregating beneficial mutations. Here, we develop an approximate Bayesian based approach that rather estimates these parameters for fixed beneficial mutations in single populations. We integrate a range of existing diversity, site frequency spectrum, haplotype and linkage disequilibrium based summary statistics. We show that for strong selective sweeps on de novo mutations the method can estimate allele age and selection strength even in non-equilibrium demographic scenarios. We extend our approach to models of selection ...
When selection is acting on a large genetically diverse population, beneficial alleles increase in f...
Allele age has long been a focus of population genetic research, primarily because it can be an impo...
Recent positive selection can increase the frequency of an advantageous mutant rapidly enough that a...
Estimating the age and strength of beneficial alleles is central to understanding how adaptation pro...
An outstanding question in human genetics has been the degree to which adaptation occurs from standi...
An outstanding question in human genetics has been the degree to which adaptation occurs from standi...
An outstanding question in human genetics has been the degree to which adaptation occurs from standi...
An outstanding question in human genetics has been the degree to which adaptation occurs from standi...
The advent of accessible ancient DNA technology now allows the direct ascertainment of allele freque...
The haplotypes of a beneficial allele carry information about its history that can shed light on its...
When selection is acting on a large genetically diverse population, beneficial alleles increase in f...
Isolated populations with novel phenotypes present an exciting opportunity to uncover the genetic ba...
Isolated populations with novel phenotypes present an exciting opportunity to uncover the genetic ba...
Evolutionary geneticists have sought to characterize the causes and molecular targets of selection i...
Adaptive genetic variation is a function of both selective and neutral forces. To accurately identif...
When selection is acting on a large genetically diverse population, beneficial alleles increase in f...
Allele age has long been a focus of population genetic research, primarily because it can be an impo...
Recent positive selection can increase the frequency of an advantageous mutant rapidly enough that a...
Estimating the age and strength of beneficial alleles is central to understanding how adaptation pro...
An outstanding question in human genetics has been the degree to which adaptation occurs from standi...
An outstanding question in human genetics has been the degree to which adaptation occurs from standi...
An outstanding question in human genetics has been the degree to which adaptation occurs from standi...
An outstanding question in human genetics has been the degree to which adaptation occurs from standi...
The advent of accessible ancient DNA technology now allows the direct ascertainment of allele freque...
The haplotypes of a beneficial allele carry information about its history that can shed light on its...
When selection is acting on a large genetically diverse population, beneficial alleles increase in f...
Isolated populations with novel phenotypes present an exciting opportunity to uncover the genetic ba...
Isolated populations with novel phenotypes present an exciting opportunity to uncover the genetic ba...
Evolutionary geneticists have sought to characterize the causes and molecular targets of selection i...
Adaptive genetic variation is a function of both selective and neutral forces. To accurately identif...
When selection is acting on a large genetically diverse population, beneficial alleles increase in f...
Allele age has long been a focus of population genetic research, primarily because it can be an impo...
Recent positive selection can increase the frequency of an advantageous mutant rapidly enough that a...