Localization of Laminin Relative to Alpha 1 Integrin in Embryonic Chick Skeletal Muscle

Background:The spatial and temporal localization of laminin in relation to alpha 1 integrin is examined in chick skeletal muscle. Periodic colocalization of alpha 1 integrin and laminin have previously been observed on myofibers in cultured embryonic chick skeletal muscle as early as day 3 in culture. Similar to the spatial localization found in cultured skeletal muscle, alpha 1 integrin is found with a periodic sarcomeric distribution in sectioned skeletal muscle from chick embryos beginning on embryonic day 13