The enigma of uric acid in metabolic syndrome

Metabolic syndrome is a group of risk factors including an increased level of triglycerides, fasting blood glucose, blood pressure or waist circumference, and or a decreased level of HDL cholesterol. The level of uric acid in the blood has been associated with the presence of metabolic syndrome, which can aggravate the prognosis of cardiovascular diseases, type 2 diabetes mellitus and stroke. On the interest to identify the early biomarkers of metabolic syndrome, Popovic et al involved 1333 patients and showed using logistic regression that a significant association between the blood levels of uric acid in the subjects diagnosed with metabolic syndrome and in the group of obese patients, who had the body mass index of more than 30 kg/m2. This study shed some light in identifying a metabolically unhealthy phenotype