Chiral Recognition in the Inclusion Complex of Cyclodextrins with N-Dansyl-Phenylalanine Observed by Linked Scan FAB-MS Spectrometry

服部憲治郎
MOTOOKA Seiji
高橋圭子
Kenjiro HATTORI
Seiji MOTOOKA
Keiko TAKAHASHI
Department of Applied Chemistry, Faculty of Engineering, Tokyo Institute of Polytechnics
Graduate School, Tokyo Institute of Polytechnics (TOYOBO Engineering, Co,. Ltd.)
Department of Applied Chemisty, Facnlty ot Engineering, Tokyo Institute of Polytechnics

Publication date

January 1999

Abstract

The cyclodextrin (CD) inclusion complex showed a chiral recognition observed by linked scan FAB-MS. The ratio, R, of the daughter ionic peak strength to the precursor ionic peak strength using the linked scan FAB-MS method was suggested to express a parameter for the stability of CD inclusion complex. The ratios between R_D and R_L were determined in inclusion complexes consisted of D-and L-N-dansyl-phenylalanines with various CDs. As for this parameter R derived from the linked scan FAB-MS ionic peaks, the wide application is possible to the inclusion complexes and the evaluation of the chiral recognition in various inclusion complexes